Inflammatory breast cancer appearance at presentation is associated with overall survival

Autor:	Wendy A. Woodward, Diane Liu, Randa El-Zein, Naoto T. Ueno, Yu Shen, Bisrat G. Debeb, Kathy D. Miller, Wintana Balema, Beth Overmoyer, Huong T. Le-Petross, Megumi Kai
Rok vydání:	2021
Předmět:	Adult Cancer Research medicine.medical_specialty Wilcoxon signed-rank test IBC Physical examination Disease Kaplan-Meier Estimate peau d'orange Inflammatory breast cancer Breast cancer breast cancer Internal medicine medicine Peau d'orange Humans Radiology Nuclear Medicine and imaging redness skin thickening Breast Prospective Studies skin and connective tissue diseases RC254-282 Mastectomy Research Articles Aged T4D Aged 80 and over medicine.diagnostic_test business.industry Proportional hazards model Neoplasms. Tumors. Oncology. Including cancer and carcinogens Clinical Cancer Research Middle Aged medicine.disease Prognosis Neoadjuvant Therapy Exact test Oncology Chemotherapy Adjuvant Female Inflammatory Breast Neoplasms medicine.symptom breast swelling business erythema Research Article
Zdroj:	Cancer Medicine Cancer Medicine, Vol 10, Iss 18, Pp 6261-6272 (2021)
ISSN:	2045-7634
Popis:	Background Inflammatory breast cancer (IBC) is a clinical diagnosis. Here, we examined the association of a “classic” triad of clinical signs, swollen involved breast, nipple change, and diffuse skin change, with overall survival (OS). Method Breast medical photographs from patients enrolled on a prospective IBC registry were scored by two independent reviewers as classic (triad above), not classic, and difficult to assign. Chi‐squared test, Fisher's exact test, and Wilcoxon rank‐sum test were used to assess differences between patient groups. Kaplan–Meier estimates and the log‐rank test and Cox proportional hazard regression were used to assess the OS. Results We analyzed 245 IBC patients with median age 54 (range 26–81), M0 versus M1 status (157 and 88 patients, respectively). The classic triad was significantly associated with smoking, post‐menopausal status, and metastatic disease at presentation (p = 0.002, 0.013, and 0.035, respectively). Ten‐year actuarial OS for not classic and difficult to assign were not significantly different and were grouped for further analyses. Ten‐year OS was 29.7% among patients with the classic sign triad versus 57.2% for non‐classic (p Inflammatory breast cancer (IBC) is a clinical diagnosis. Here, we examined the association of a “classic” triad of clinical signs, swollen involved breast, nipple change, and diffuse skin change, with overall survival (OS). Our study concluded for the first time that a triad of classic IBC signs independently predicted OS in patients diagnosed with IBC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27aac0604bef52535a662c9f9b6c6cb2 https://pubmed.ncbi.nlm.nih.gov/34327874 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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