A dissociation of the acute effects of Bupropion on positive emotional processing and reward processing in healthy volunteers
| Autor: | Michael Browning, Randi Brown, Annabel E. L. Walsh, Catherine J. Harmer, Phil J. Cowen, Nathan T. M. Huneke |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
lcsh:RC435-571 media_common.quotation_subject emotion Audiology Placebo 03 medical and health sciences 0302 clinical medicine lcsh:Psychiatry mental disorders medicine reward media_common Recognition memory Original Research Bupropion Psychiatry business.industry Anhedonia Response bias 030227 psychiatry Psychiatry and Mental health anhedonia Mood antidepressants depression behavior and behavior mechanisms Antidepressant medicine.symptom dopamine business 030217 neurology & neurosurgery psychological phenomena and processes medicine.drug Vigilance (psychology) |
| Zdroj: | Frontiers in Psychiatry, Vol 9 (2018) Frontiers in Psychiatry |
| DOI: | 10.3389/fpsyt.2018.00482 |
| Popis: | Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, less is known about the effect of antidepressants on reward processing despite the potential relevance to the treatment of anhedonia. In this study, we investigated the effects of an acute dose of the atypical antidepressant (dual dopamine and noradrenaline reuptake inhibitor) bupropion on behavioral measures of emotional and reward processing in healthy volunteers. Methods: Forty healthy participants were randomly allocated to double-blind intervention with either an acute dose of bupropion or placebo prior to performing the Emotional Test Battery (ETB) and a probabilistic instrumental learning task. Results: Acute bupropion significantly increased the recognition of ambiguous faces as happy, decreased response bias toward sad faces and reduced attentional vigilance for fearful faces compared to placebo. Bupropion also reduced negative bias compared to placebo in the emotional recognition memory task (EMEM). There was no evidence that bupropion enhanced reward processing or learning. Instead, bupropion was associated with reduced likelihood to choose high-probability wins and increased score on a subjective measure of anhedonia. Conclusions: Whilst acute bupropion decreases negative and increases positive emotional processing, it has an adverse effect on reward processing. There seems to be a dissociation of the acute effects of bupropion on positive emotional processing and reward processing, which may have clinical implications for anhedonia early in treatment. |
| Databáze: | OpenAIRE |
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