The circulating lymphocyte profiles in patients with discoid lupus erythematosus and systemic lupus erythematosus suggest a pathogenetic relationship
| Autor: | Jan Ceuppens, Hugo Degreef, Erik Stevens, C Diegenant, Carine Wouters |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Systemic disease Pathology medicine.medical_specialty Adolescent Discoid lupus erythematosus Lymphocyte B-Lymphocyte Subsets Dermatology CD8-Positive T-Lymphocytes Antimalarials Lupus Erythematosus Discoid Immune system Antigens CD T-Lymphocyte Subsets immune system diseases medicine Humans Lupus Erythematosus Systemic Lymphocytes skin and connective tissue diseases Aged Lupus erythematosus business.industry HLA-DR Antigens Middle Aged Flow Cytometry medicine.disease Connective tissue disease medicine.anatomical_structure Peripheral blood lymphocyte Immunology Female CD5 business |
| Zdroj: | British Journal of Dermatology. 150:693-700 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.0007-0963.2004.05883.x |
| Popis: | Summary Background Discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) are chronic inflammatory diseases of unknown aetiology; the relationship of DLE with SLE has been a subject of debate for many years. Objectives To find evidence for systemic immune activation in DLE by analysis of the immunophenotypic profiles of circulating lymphocytes, and to compare these changes with those in patients with SLE. Methods The immunophenotypic profile of peripheral blood lymphocyte subsets from 23 DLE patients without clinical or laboratory evidence of systemic disease, 25 SLE patients and 38 healthy donors was characterized by two-colour immunofluorescence flow cytometry analysis. None of the patients was receiving corticosteroid or immunosuppressive treatment. Results Patients with DLE had increased numbers of circulating HLA-DR+ CD3+ T cells and HLA-DR+ CD4+ T cells, indicating systemic T-cell activation, and an expansion of CD5+ CD19+ B cells. Decreased numbers of T-cell subsets expressing the differentiation markers CD11b and CD16/56, and of CD16/56+ natural killer cells were also found. In SLE, the changes were similar but more pronounced. In addition, a profound CD4+ T-cell lymphopenia and an increase of HLA-DR+ CD8+ T cells were found only in SLE. Conclusions Our data provide evidence for systemic activation of the cellular immune system in patients with purely cutaneous DLE. Similarities in the lymphocyte immunophenotypic profiles in patients with DLE compared with SLE suggest that there are common immunopathological processes in these two conditions. |
| Databáze: | OpenAIRE |
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