HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia

Autor: Patrick Byanyima, Richard J. Wang, Rejani Lalitha, Daniela Moisi, Kristina Crothers, Michael M. Lederman, J. Lucian Davis, Sylvia Kaswabuli, Emmanuel Musisi, Abdulwahab Sessolo, Ingvar Sanyu, Peter W. Hunt, Jue Lin, Laurence Huang, William Worodria, Emily Chang, Julia Moore
Přispěvatelé: Apetrei, Cristian
Rok vydání: 2019
Předmět:
Male
RNA viruses
0301 basic medicine
Pulmonology
Lipopolysaccharide Receptors
HIV Infections
Pathology and Laboratory Medicine
Biochemistry
Monocytes
Receptors
Tumor Necrosis Factor
Cohort Studies
0302 clinical medicine
Immunodeficiency Viruses
Heart Rate
Receptors
2.1 Biological and endogenous factors
Uganda
Prospective Studies
030212 general & internal medicine
Aetiology
Hyaluronic Acid
Prospective cohort study
Lung
Multidisciplinary
biology
HIV diagnosis and management
Middle Aged
Obstructive lung disease
CD
3. Good health
Infectious Diseases
C-Reactive Protein
Medical Microbiology
Viral Pathogens
Viruses
Cohort
Pneumonia & Influenza
HIV/AIDS
Infectious diseases
Tuberculosis Diagnosis and Management
Medicine
Biomarker (medicine)
Female
Pathogens
medicine.symptom
Infection
Research Article
Cohort study
Adult
General Science & Technology
Science
Immunology
Cardiology
Inflammation
Viral diseases
Microbiology
Fibrin Fibrinogen Degradation Products
Immune Activation
03 medical and health sciences
Clinical Research
Antigens
CD
Retroviruses
medicine
Humans
Antigens
Interleukin 6
Microbial Pathogens
Medicine and health sciences
Interleukin-6
business.industry
Inflammatory and immune system
Lentivirus
Immunity
Organisms
Biology and Life Sciences
HIV
Pneumonia
medicine.disease
030112 virology
Diagnostic medicine
Good Health and Well Being
Cross-Sectional Studies
biology.protein
Tumor Necrosis Factor
business
Biomarkers
Zdroj: PLoS ONE, Vol 14, Iss 5, p e0216680 (2019)
PLoS ONE
PloS one, vol 14, iss 5
ISSN: 1932-6203
Popis: Author(s): Wang, Richard J; Moore, Julia; Moisi, Daniela; Chang, Emily G; Byanyima, Patrick; Kaswabuli, Sylvia; Musisi, Emmanuel; Sanyu, Ingvar; Sessolo, Abdulwahab; Lalitha, Rejani; Worodria, William; Davis, J Lucian; Crothers, Kristina; Lin, Jue; Lederman, Michael M; Hunt, Peter W; Huang, Laurence | Abstract: IntroductionPneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.MethodsThe Inflammation, Aging, Microbes, and Obstructive Lung Disease (I AM OLD) Cohort is a prospective cohort of adults with pneumonia in Uganda. In this cross-sectional analysis, plasma was collected at pneumonia presentation to measure the following 12 biomarkers: interleukin 6 (IL-6), soluble tumor necrosis factor receptors 1 and 2 (sTNFR-1 and sTNFR-2), high sensitivity C-reactive protein (hsCRP), fibrinogen, D-dimer, soluble CD27 (sCD27), interferon gamma-inducible protein 10 (IP-10), soluble CD14 (sCD14), soluble CD163 (sCD163), hyaluronan, and intestinal fatty acid binding protein. We asked whether biomarker levels differed between HIV-infected and HIV-uninfected participants, and whether higher levels of these biomarkers were associated with mortality.ResultsOne hundred seventy-three participants were enrolled. Fifty-three percent were HIV-infected. Eight plasma biomarkers-sTNFR-1, sTNFR-2, hsCRP, D-dimer, sCD27, IP-10, sCD14, and hyaluronan-were higher among participants with HIV infection, after adjustment for pneumonia severity. Higher levels of 8 biomarkers-IL-6, sTNFR-1, sTNFR-2, hsCRP, IP-10, sCD14, sCD163, and hyaluronan-were associated with increased 2-month mortality.ConclusionsAs in other clinical contexts, HIV infection is associated with a greater degree of immune activation among Ugandan adults with pneumonia. Some of these are also associated with short-term mortality. Further study is needed to explore whether these biomarkers might predict poor long-term outcomes-such as the development of obstructive lung disease-in patients with HIV who have recovered from pneumonia.
Databáze: OpenAIRE
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