Comprehensive cardiovascular magnetic resonance of myocardial mechanics in mice using three-dimensional cine DENSE

Autor: Andrew D Gilliam, Xiaodong Zhong, Lauren B Gibberman, Brent A. French, Bruce S Spottiswoode, Frederick H. Epstein, Craig H. Meyer
Přispěvatelé: MRC/UCT Medical Imaging Research Unit, Faculty of Health Sciences
Rok vydání: 2011
Předmět:
Cardiac function curve
lcsh:Diseases of the circulatory (Cardiovascular) system
Noninvasive imaging
medicine.medical_specialty
Time Factors
Heart Ventricles
Magnetic Resonance Imaging
Cine
030204 cardiovascular system & hematology
Ventricular Function
Left
030218 nuclear medicine & medical imaging
Myocardial mechanics
03 medical and health sciences
Mice
0302 clinical medicine
Imaging
Three-Dimensional
Internal medicine
Image Interpretation
Computer-Assisted
medicine
Animals
Radiology
Nuclear Medicine and imaging
Angiology
Medicine(all)
3D cine DENSE pulse sequence
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Biomechanics
Magnetic resonance imaging
Stroke Volume
Stroke volume
Myocardial Contraction
Biomechanical Phenomena
Mice
Inbred C57BL
lcsh:RC666-701
Cardiology
Technical Notes
Cardiology and Cardiovascular Medicine
business
Cardiac phase
Zdroj: Journal of Cardiovascular Magnetic Resonance
Journal of Cardiovascular Magnetic Resonance, Vol 13, Iss 1, p 83 (2011)
ISSN: 1532-429X
Popis: Background Quantitative noninvasive imaging of myocardial mechanics in mice enables studies of the roles of individual genes in cardiac function. We sought to develop comprehensive three-dimensional methods for imaging myocardial mechanics in mice. Methods A 3D cine DENSE pulse sequence was implemented on a 7T small-bore scanner. The sequence used three-point phase cycling for artifact suppression and a stack-of-spirals k-space trajectory for efficient data acquisition. A semi-automatic 2D method was adapted for 3D image segmentation, and automated 3D methods to calculate strain, twist, and torsion were employed. A scan protocol that covered the majority of the left ventricle in a scan time of less than 25 minutes was developed, and seven healthy C57Bl/6 mice were studied. Results Using these methods, multiphase normal and shear strains were measured, as were myocardial twist and torsion. Peak end-systolic values for the normal strains at the mid-ventricular level were 0.29 ± 0.17, -0.13 ± 0.03, and -0.18 ± 0.14 for E rr , E cc , and E ll , respectively. Peak end-systolic values for the shear strains were 0.00 ± 0.08, 0.04 ± 0.12, and 0.03 ± 0.07 for E rc , E rl , and E cl , respectively. The peak end-systolic normalized torsion was 5.6 ± 0.9°. Conclusions Using a 3D cine DENSE sequence tailored for cardiac imaging in mice at 7 T, a comprehensive assessment of 3D myocardial mechanics can be achieved with a scan time of less than 25 minutes and an image analysis time of approximately 1 hour.
Databáze: OpenAIRE
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