A Putative Vesicular Transporter Expressed in Drosophila Mushroom Bodies that Mediates Sexual Behavior May Define a Neurotransmitter System
| Autor: | Jasmine M. Haimovitz, Rafael Romero-Calderón, J. Steven de Belle, Elizabeth S. Brooks, Bac T. Nguyen, Christina L. Greer, Christine N. Serway, Rod Najibi, David E. Krantz, Anna Grygoruk, Christopher J. Tabone |
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| Rok vydání: | 2011 |
| Předmět: |
Neuroscience(all)
Vesicular Transport Proteins Neurotransmission Biology Synaptic Transmission Synaptic vesicle Article Sexual Behavior Animal 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Drosophila Proteins Neurotransmitter Mushroom Bodies 030304 developmental biology Neurons 0303 health sciences General Neuroscience food and beverages Transporter eye diseases Vesicular transport protein chemistry Mutation Mushroom bodies Drosophila Synaptic Vesicles Neuroscience 030217 neurology & neurosurgery Drosophila Protein |
| Zdroj: | Neuron. 72:316-329 |
| ISSN: | 0896-6273 |
| Popis: | Summary Vesicular transporters are required for the storage of all classical and amino acid neurotransmitters in synaptic vesicles. Some neurons lack known vesicular transporters, suggesting additional neurotransmitter systems remain unidentified. Insect mushroom bodies (MBs) are critical for several behaviors, including learning, but the neurotransmitters released by the intrinsic Kenyon cells (KCs) remain unknown. Likewise, KCs do not express a known vesicular transporter. We report the identification of a novel Drosophila gene portabella ( prt ) that is structurally similar to known vesicular transporters. Both larval and adult brains express PRT in the KCs of the MBs. Additional PRT cells project to the central complex and optic ganglia. prt mutation causes an olfactory learning deficit and an unusual defect in the male's position during copulation that is rescued by expression in KCs. Because prt is expressed in neurons that lack other known vesicular transporters or neurotransmitters, it may define a previously unknown neurotransmitter system responsible for sexual behavior and a component of olfactory learning. Video Abstract |
| Databáze: | OpenAIRE |
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