The AP2-type transcription factors DORNRÖSCHEN and DORNRÖSCHEN-LIKE promote G1/S transition
| Autor: | Wolfgang Werr, John W. Chandler, Anneke Frerichs, Petra Comelli, Ingo Seeliger, Dorothea Glowa, Laura Velo |
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| Rok vydání: | 2016 |
| Předmět: |
0106 biological sciences
0301 basic medicine Transgene Meristem Arabidopsis Biology 01 natural sciences Gene Knockout Techniques 03 medical and health sciences Transcription (biology) Genetics Promoter Regions Genetic Molecular Biology Transcription factor Gene Cell Proliferation Homeodomain Proteins Arabidopsis Proteins fungi food and beverages G1/S transition General Medicine Cell cycle biology.organism_classification G1 Phase Cell Cycle Checkpoints 030104 developmental biology Plant Shoots Transcription Factors 010606 plant biology & botany |
| Zdroj: | Molecular Genetics and Genomics. 291:1835-1849 |
| ISSN: | 1617-4623 1617-4615 |
| Popis: | The paralogous genes DORNRÖSCHEN (DRN) and DORNRÖSCHEN-LIKE (DRNL) encode AP2-type transcription factors that are expressed and act cell-autonomously in the central stem-cell zone or lateral organ founder cells (LOFCs) in the peripheral zone of the Arabidopsis shoot meristem (SAM), but their molecular contribution is unknown. Here, we show using the Arabidopsis thaliana MERISTEM LAYER 1 promoter that DRN and DRNL share a common function in cell cycle progression and potentially provide local competence for G1-S transitions in the SAM. Analysis of double transgenic DRN::erGFP and DRNL::erCERULEAN promoter fusion lines suggests that the trajectory of this cellular competence starts with DRN activity in the central stem-cell zone and extends locally via DRNL activity into groups of founder cells at the IM or FM periphery. Our data support the scenario that after gene duplication, DRN and DRNL acquired different transcription domains within the shoot meristem, but retained protein function that affects cell cycle progression, either centrally in stem cells or peripherally in primordial founder cells, a finding that is of general relevance for meristem function. |
| Databáze: | OpenAIRE |
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