Patterns ofin VitroAnti-Human Immunodeficiency Virus Type 1 Antibody Production in Long-Term Nonprogressors
| Autor: | Chiara De Maddalena, Maria Chiara Colombo, Stefano Rusconi, Alberto Berlusconi, Massimo Galli, Patrizia Bagnarelli, Claudia Balotta, L. Papagno, Agostino Riva |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Sialoglycoproteins Immunology HIV Antibodies HIV Envelope Protein gp120 Peripheral blood mononuclear cell Asymptomatic Virus Pathology and Forensic Medicine HIV Seropositivity medicine Humans Immunology and Allergy Sida Acquired Immunodeficiency Syndrome biology biology.organism_classification Virology CD4 Lymphocyte Count Lentivirus Disease Progression HIV-1 biology.protein Female Viral disease Antibody medicine.symptom Viral load |
| Zdroj: | Clinical Immunology and Immunopathology. 85:320-323 |
| ISSN: | 0090-1229 |
| DOI: | 10.1006/clin.1997.4470 |
| Popis: | With the aim of evaluating the specific pattern of in vitro antibody production (IVAP) in human immunodeficiency virus type 1 (HIV-1)-infected long-term nonprogressors (LTNPs), we tested 20 subjects who had remained asymptomatic for more than 8 years with a CD4 + cell count higher than 500/μl and 59 patients at different stages of HIV-1 infection as controls. In cell cultures, IVAP was detected in 14 out of 20 LTNPs (70%), in 5 out of 6 recent seroconverters (83%), and in all the other control patients. Anti-p24 antibody production was significantly lower in LTNPs than in asymptomatic patients with a more recent infection. Recent seroconverters and patients with AIDS did not produce anti-p24 antibodies ( P = 0.02). Anti-gp160 antibodies were produced by peripheral blood mononuclear cells from LTNPs in 12/20 cases. CD4 + cell count was significantly higher in IVAP-negative than in IVAP-positive LTNPs ( P = 0.013), while the viral load was not significantly different. Specific anti-HIV-1 antibody production did not seem to be a correlate of long-term nonprogression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect