Inflammatory bowel disease is associated with increased mucosal levels of bactericidal/permeability-increasing protein
| Autor: | S. J. H. Van Deventer, G. N. J. Tytgat, D. O. Obradov, P. W. Trown, H. Monajemi, J. Meenan, S. A. Radema, R. Lamping |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Adolescent Colon Neutrophils Biopsy Blotting Western Enzyme-Linked Immunosorbent Assay Inflammatory bowel disease Sepsis Intestinal mucosa Crohn Disease medicine Animals Humans Colitis Intestinal Mucosa Hepatology medicine.diagnostic_test biology business.industry Gastroenterology Membrane Proteins Blood Proteins Middle Aged medicine.disease Bactericidal/permeability-increasing protein Inflammatory Bowel Diseases Ulcerative colitis Blood proteins Immunohistochemistry Immunology biology.protein Colitis Ulcerative Female business Antimicrobial Cationic Peptides |
| Zdroj: | Gastroenterology, 110(3), 733-739. W.B. Saunders Ltd |
| ISSN: | 0016-5085 |
| Popis: | Clinical sepsis seldom accompanies inflammatory bowel disease. The aim of this study was to measure colonic mucosal levels of the neutrophil product bactericidal/permeability-increasing protein (BPI), which kills gram-negative bacteria in addition to inactivating endotoxin. Enzyme-linked immunosorbent assay and immunohistochemistry for BPI were performed on homogenates and tissue secretions of biopsy specimens from patients with ulcerative colitis (n=11) and Crohn's disease (n=5) and from normal controls (n=5). Mucosal neutrophil content (144 +/- 23 vs. 35 +/- 9 neutrophils/mg protein; P |
| Databáze: | OpenAIRE |
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