Antibody response and ribonuclease activity in the sera of calves passively immunized to bovine pancreatic ribonuclease
| Autor: | G. Wilson, J.A. Bukovic, G. Hoffsiss, H.M. Johnson, Bennett G. Smith |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Epinephrine
Ovalbumin Immunology Egg albumin Serum albumin Bovine pancreatic ribonuclease Ribonucleases Iodine Isotopes Immunology and Allergy Animals Ribonuclease Bovine serum albumin Anaphylaxis Pancreas biology Immune Sera Serum Albumin Bovine General Medicine Hemagglutination Tests Molecular biology Antibody response Diphenhydramine Antibody Formation biology.protein Pancreatic ribonuclease Cattle Rabbits Immunity Maternally-Acquired |
| Zdroj: | International archives of allergy and applied immunology. 44(6) |
| ISSN: | 0020-5915 |
| Popis: | Calves passively immunized with rabbit anti-bovine pancreatic ribonuclease serum were examined for their antibody response to egg albumin, rabbit γ-globulin, and rabbit serum albumin. An enhanced immune response was observed toward rabbit γ-globulin, but not toward the other antigens. It appears that this enhanced response to rabbit γ-globulin was due to the formation of ribonuclease-anti-ribonuclease complexes in vivo, and was directed toward antigenic determinants on the rabbit anti-ribonuclease antibody. Concomitant with the antibody response was an increase in the concentration of serum ribonuclease as determined by radioimmunoassay. A corresponding increase in ribonuclease enzymatic activity, however, was not generally observed. The data suggest a possible interaction between ribonuclease, a ribonuclease inhibitor, and the apparatus for antibody synthesis. |
| Databáze: | OpenAIRE |
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