Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings
| Autor: | Yo Han Jeon, Ji Hyun Park, Min-ju Kim, Sang-Joon Choi, Jeong-Wook Seo, Nam Seok Yeo, Jong Kyu Lee, SangHan Lee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Myocarditis Necrosis business.industry Vaccination Contraction band necrosis Case Report Autopsy General Medicine Infectious Diseases Microbiology & Parasitology Adverse Event Following Immunization medicine.disease Sudden Cardiac Death Sudden death Sudden cardiac death Coronavirus Disease 19 medicine mRNA Vaccines medicine.symptom business Histiocyte Cause of death |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| DOI: | 10.3346/jkms.2021.36.e286 |
| Popis: | We present autopsy findings of a 22-year-old man who developed chest pain 5 days after the first dose of the BNT162b2 mRNA vaccine and died 7 hours later. Histological examination of the heart revealed isolated atrial myocarditis, with neutrophil and histiocyte predominance. Immunohistochemical C4d staining revealed scattered single-cell necrosis of myocytes which was not accompanied by inflammatory infiltrates. Extensive contraction band necrosis was observed in the atria and ventricles. There was no evidence of microthrombosis or infection in the heart and other organs. The primary cause of death was determined to be myocarditis, causally-associated with the BNT162b2 vaccine. Graphical Abstract |
| Databáze: | OpenAIRE |
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