Serum Blood Urea Nitrogen as an Independent Marker of Subsequent Mortality Among Patients With Acute Coronary Syndromes and Normal to Mildly Reduced Glomerular Filtration Rates
| Autor: | Duane S. Pinto, C. Michael Gibson, Andrew J. Burger, Eugene Braunwald, Sabina A. Murphy, Ajay J. Kirtane, Dimitrios Karmpaliotis, Kausik K. Ray, Sushrut S. Waikar, Christopher P. Cannon, David M. Leder, Glenn M. Chertow |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Infarction Renal function urologic and male genital diseases behavioral disciplines and activities Gastroenterology Blood Urea Nitrogen Angina chemistry.chemical_compound Predictive Value of Tests Recurrence Internal medicine medicine Humans Angina Unstable Blood urea nitrogen Survival analysis Aged Retrospective Studies Creatinine biology business.industry urogenital system Syndrome Middle Aged medicine.disease biology.organism_classification Survival Analysis female genital diseases and pregnancy complications Endocrinology chemistry Tasa Circulatory system Urea Female business Cardiology and Cardiovascular Medicine Biomarkers Glomerular Filtration Rate |
| Zdroj: | Journal of the American College of Cardiology. 45(11):1781-1786 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2005.02.068 |
| Popis: | ObjectivesWe hypothesized that elevated blood urea nitrogen (BUN) would be associated with adverse outcomes independent of serum creatinine (sCr)-based estimates of kidney function in patients with acute coronary syndromes (ACS).BackgroundAlthough lower glomerular filtration rates (GFR) have prognostic significance among patients with ACS, estimates of GFR based on sCr may perform less accurately among patients with milder kidney dysfunction. In this population in particular, BUN, which can reflect increased proximal tubular reabsorption in addition to decreased GFR, may have independent prognostic value.MethodsData were drawn from 9,420 patients with unstable coronary syndromes from Orbofiban in Patients With Unstable Coronary Syndromes-Thrombolysis In Myocardial Infarction (OPUS-TIMI)-16, a trial that excluded patients with sCr >1.6 mg/dl or estimated creatinine clearance |
| Databáze: | OpenAIRE |
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