Has myelin basic protein received a fair trial in the treatment of multiple sclerosis?
| Autor: | Ellsworth C. Alvord, Sarka Hruby, Marian W. Kies, Cheng-Mei Shaw |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Central Nervous System
Encephalomyelitis Autoimmune Experimental Multiple Sclerosis medicine.drug_class Encephalomyelitis Guinea Pigs Plasma Cells Antibiotics Central nervous system Pathogenesis Mice Adjuvants Immunologic Species Specificity Antigen Animals Humans Medicine Inbreeding Lymphocytes biology business.industry Histocompatibility Testing Macrophages Multiple sclerosis Myelin Basic Protein medicine.disease Macaca mulatta Rats Myelin basic protein Macaca fascicularis medicine.anatomical_structure Neurology Immunology biology.protein Experimental pathology Neurology (clinical) business |
| Zdroj: | Annals of Neurology. 6:461-468 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.410060602 |
| Popis: | Autosensitization to some central nervous system antigen still remains one of the best hypotheses for the continuing pathogenesis of multiple sclerosis (MS). Enough is now known about the cause, pathogenesis, and treatment of experimental allergic encephalomyelitis (EAE) to test this hypothesis. Reports of therapeutic failure of the encephalitogen myelin basic protein (BP) in the treatment of MS have their counterparts in similar therapeutic failures in EAE. Only highly inbred strain 13 guinea pigs respond consistently to BP therapy, and this only when BP is administered in relatively high doses. Noninbred guinea pigs respond much less well to simple BP therapy, and monkeys hardly at all. In both strains of monkeys so far studied, a nonspecific adjunctive factor--an antibiotic in Macaca mulatta and a steroid in Macaca fascicularis--is also required. Accordingly, human trials of the therapeutic efficacy of BP in MS should include its administration in large concentrations together with an adjunctive agent. |
| Databáze: | OpenAIRE |
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