Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride
| Autor: | Bayram Güner, Ebru Yildirim, Ruhi Kabakçi, Nurgül Atmaca, Fatih Sultan Bilmen |
|---|---|
| Přispěvatelé: | Kırıkkale Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Article Subject lcsh:Medicine Hematocrit Resveratrol General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Elevated alt Fluorides Internal medicine Stilbenes medicine Leukocytes Animals Adverse effect Inorganic phosphorus skin and connective tissue diseases General Immunology and Microbiology biology medicine.diagnostic_test Chemistry lcsh:R food and beverages General Medicine Wbc count Enzyme assay Rats Endocrinology Biochemistry biology.protein Fluoride Research Article |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | We investigated the protective effects of resveratrol on hematological and biochemical changes induced by fluoride in rats. A total of 28 rats were divided into 4 groups: control, resveratrol, fluoride, and fluoride/resveratrol(n=7each), for a total of 21 days of treatment. Blood samples were taken and hematological and biochemical parameters were measured. Compared to the control group, the fluoride-treated group showed significant differences in several hematological parameters, including decreases in WBC, RBC, and PLT counts and neutrophil ratio. The group that received resveratrol alone showed a decrease in WBC count compared to the control group. Furthermore, in comparison to the control group, the fluoride group showed significantly increased ALT enzyme activity and decreased inorganic phosphorus level. The hematological and biochemical parameters in the fluoride + resveratrol treated group were similar to control group. In the fluoride + resveratrol group, resveratrol restored the changes observed following fluoride treatment, including decreased counts of WBC, RBC, and PLT, decreased neutrophil ratio and inorganic phosphorus levels, and elevated ALT enzyme activity. The present study showed that fluoride caused adverse effects in rats and that resveratrol reduced hematological and biochemical alterations produced by fluoride exposure. |
| Databáze: | OpenAIRE |
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