Effect of metabolic genetic variants on long-term disease comorbidity in patients with type 2 diabetes
| Autor: | Abedian, Shifteh, Abbasi, Ali, de Boer, Anthonius, Stricker, Bruno H, Bakker, Stephan J L, van der Harst, Pim, Sedaghat, Sanaz, Darvishian, Maryam, Ikram, M Arfan, Navis, Gerjan, Dehghan, Abbas, Pen, Ido, Stolk, Ronald P, Snieder, Harold, Klungel, Olaf H, Souverein, Patrick, Alizadeh, Behrooz Z, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology |
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| Přispěvatelé: | Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Value, Affordability and Sustainability (VALUE), Pen group, Life Course Epidemiology (LCE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Epidemiology |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Eye Diseases Science Eye disease Diseases Single-nucleotide polymorphism Comorbidity Disease Type 2 diabetes 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Article 03 medical and health sciences Medical research 0302 clinical medicine SDG 3 - Good Health and Well-being Risk Factors Neoplasms Internal medicine Genetics Humans Medicine Genetic Predisposition to Disease Renal Insufficiency Chronic Aged Multidisciplinary business.industry Incidence Incidence (epidemiology) Middle Aged medicine.disease 030104 developmental biology Diabetes Mellitus Type 2 Cardiovascular Diseases Female Nervous System Diseases business Pharmacogenetics Follow-Up Studies Kidney disease |
| Zdroj: | Scientific Reports Scientific Reports, 11(1). NLM (Medline) Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) Scientific Reports, 11(1):2794. Nature Publishing Group |
| ISSN: | 2045-2322 |
| Popis: | Underlying genetic determinants contribute to developing type 2 diabetes (T2D) future diseases. The present study aimed to identify which genetic variants are associated with the incident of the major T2D co-morbid disease. First, we conducted a discovery study by investigating the genetic associations of comorbid diseases within the framework of the Utrecht Cardiovascular Pharmacogenetic studies by turning information of > 25 years follow-up data of 1237 subjects whom were genotyped and included in the discovery study. We performed Cox proportional-hazards regression to examine associations between genetic variants and comorbid diseases including cardiovascular diseases (CVD), chronic eye disease, cancer, neurologic diseases and chronic kidney disease. Secondly, we replicated our findings in two independent cohorts consisting of 1041 subjects. Finally, we performed a meta-analysis by combining the discovery and two replication cohorts. We ascertained 390 (39.7%) incident cases of CVD, 182 (16.2%) of chronic eye disease, 155 (13.8%) of cancer, 31 (2.7%) of neurologic disease and 13 (1.1%) of chronic kidney disease during a median follow-up of 10.2 years. In the discovery study, we identified a total of 39 Single Nucleotide Polymorphisms (SNPs) associated with comorbid diseases. The replication study, confirmed that rs1870849 and rs8051326 may play a role in the incidence of chronic eye disease in T2D patients. Half of patients developed at least one comorbid disease, with CVD occurring most often and earliest followed by chronic eye disease. Further research is needed to confirm the associations of two associated SNPs with chronic eye disease in T2D. |
| Databáze: | OpenAIRE |
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