Expression of estrogen receptor β in normal skin, melanocytic nevi and malignant melanomas
| Autor: | Chika Ohata, Taketsugu Tadokoro, Satoshi Itami |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male endocrine system Pathology medicine.medical_specialty Skin Neoplasms Adolescent Estrogen receptor Human skin Dermatology Melanin polycyclic compounds medicine Estrogen Receptor beta Humans Nevus Child Melanoma reproductive and urinary physiology Estrogen receptor beta Aged Nevus Pigmented integumentary system business.industry Estrogen Receptor alpha Infant General Medicine Middle Aged Melanocytic nevus medicine.disease Case-Control Studies Child Preschool Immunohistochemistry Female business Estrogen receptor alpha hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of Dermatology. 35:215-221 |
| ISSN: | 1346-8138 0385-2407 |
| DOI: | 10.1111/j.1346-8138.2008.00447.x |
| Popis: | Sex hormones are known to be associated with increases of melanocytes and melanin production in human skin. However, the expression of estrogen receptor (ERalpha) in melanocytic lesions has been controversial. In 1996, a new subset of estrogen receptor was cloned, and named estrogen receptor beta (ERbeta). We used immunohistochemical staining to characterize the expression of ERalpha and ERbeta in normal skin and in melanocytic lesions. Normal sebaceous glands and hair follicles were positive for ERalpha and ERbeta. Other adnexal structures and constituents in the skin were positive for ERbeta, but not for ERalpha. Melanocytic nevi and malignant melanomas were negative for ERalpha, but both were positive for ERbeta. The ubiquitous expression of ERbeta may play a fundamental role in various normal skin cells and melanocytic tumors. |
| Databáze: | OpenAIRE |
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