Experimental elicitation with hydroxyisohexyl-3-cyclohexene carboxaldehyde-containing deodorants
| Autor: | Klaus Ejner Andersen, Pia Haslund Jørgensen, Charlotte D Jensen, Suresh Chandra Rastogi, Jeanne D. Johansen |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Allergy Cyclohexanecarboxylic Acids medicine.medical_treatment Dermatology medicine.disease_cause Risk Assessment Allergen Double-Blind Method Hydroxyisohexyl 3-cyclohexene carboxaldehyde Cyclohexenes medicine Humans Immunology and Allergy Threshold Limit Values Allergic contact dermatitis Aldehydes Deodorants business.industry Patch test Allergens Middle Aged Patch Tests medicine.disease Fragrance allergy Contact allergy Dermatitis Allergic Contact Immunology Deodorant Female business |
| Zdroj: | Jørgensen, P H, Jensen, C D, Rastogi, S, Andersen, K E & Johansen, J D 2007, ' Experimental elicitation with hydroxyisohexyl-3-cyclohexene carboxaldehyde-containing deodorants ', Contact Dermatitis, vol. 56, no. 3, pp. 146-50 . https://doi.org/10.1111/j.1600-0536.2007.01028.x Jørgensen, P H, Jensen, C D, Rastogi, S C, Andersen, K E & Johansen, J D 2007, ' Experimental elicitation with hydroxyisohexyl-3-cyclohexene carboxaldehyde-containing deodorant ', Contact Dermatitis, vol. 56, no. 3, pp. 146-150 . |
| ISSN: | 1600-0536 0105-1873 |
| Popis: | Udgivelsesdato: 2007-Mar Hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC) known as Lyral is a frequent allergen. It is used in more than 50% of marketed deodorants. The aim of the present study was to determine elicitation thresholds for HICC under simulated conditions of deodorant use. 15 patients with previously diagnosed contact allergy to HICC were patch tested with 5 solutions of HICC-scented and HICC-unscented deodorants. Patients and 10 healthy controls performed a use test in the axillae using deodorants scented with HICC in increasing concentrations and unscented deodorants as control. The concentration of HICC was increased every second week (200, 600, and 1800 p.p.m.) until either a reaction developed or for 6 weeks. 14 patients completed the study, and all developed unilateral eczema from the HICC-containing deodorant, while controls were all negative (P= 0.004). In 9/14 patients, a positive use test developed during the first 2 weeks to the deodorant containing 200 p.p.m. HICC. Positive correlations were found between the day of positive use and patch test threshold concentration of the HICC solutions (r= 0.71, P= 0.01) as well as the patch test thresholds of the HICC-scented deodorants (r= 0.74, P= 0.007). In conclusion, HICC elicits allergic contact dermatitis in a high proportion of sensitized individuals at common usage concentrations in deodorants. |
| Databáze: | OpenAIRE |
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