Strategies to Better Target Fungal Squalene Monooxygenase
| Autor: | Alia A. Sagatova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
dermatophytes Squalene monooxygenase Sterol Biosynthesis Pathway X-ray crystal structures Plant Science Review Biology squalene terbinafine 2 3-Oxidosqualene 2 3-oxidosqualene 03 medical and health sciences chemistry.chemical_compound Human health Squalene antimycotics lcsh:QH301-705.5 Ecology Evolution Behavior and Systematics 030304 developmental biology chemistry.chemical_classification 0303 health sciences Ergosterol ergosterol 030306 microbiology ergosterol biosynthesis pathway squalene monooxygenase NB-598 Enzyme Oxygen atom chemistry Biochemistry lcsh:Biology (General) fungal infections resistance mutations antifungals |
| Zdroj: | Journal of Fungi Journal of Fungi, Vol 7, Iss 49, p 49 (2021) |
| ISSN: | 2309-608X |
| Popis: | Fungal pathogens present a challenge in medicine and agriculture. They also harm ecosystems and threaten biodiversity. The allylamine class of antimycotics targets the enzyme squalene monooxygenase. This enzyme occupies a key position in the sterol biosynthesis pathway in eukaryotes, catalyzing the rate-limiting reaction by introducing an oxygen atom to the squalene substrate converting it to 2,3-oxidosqualene. Currently, terbinafine—the most widely used allylamine—is mostly used for treating superficial fungal infections. The ability to better target this enzyme will have significant implications for human health in the treatment of fungal infections. The human orthologue can also be targeted for cholesterol-lowering therapeutics and in cancer therapies. This review will focus on the structural basis for improving the current therapeutics for fungal squalene monooxygenase. |
| Databáze: | OpenAIRE |
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