Myocardial infarction in the dog: Effects of intravenous propranolol
| Autor: | E. Welman, Kim Fox, Andrew P. Selwyn |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Myocardial Infarction Infarction Blood Pressure Propranolol Anterior Descending Coronary Artery Electrocardiography Dogs Heart Rate Internal medicine medicine Animals Myocardial infarction Creatine Kinase Radioisotopes business.industry Myocardial metabolism Myocardium Krypton medicine.disease Arterial occlusion Coronary occlusion Anesthesia Injections Intravenous Cardiology Cardiology and Cardiovascular Medicine business Perfusion medicine.drug |
| Zdroj: | The American Journal of Cardiology. 45:769-774 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(80)90120-4 |
| Popis: | The effects of propranolol on myocardial perfusion and metabolism during acute myocardial infarction were studied in 18 mongrel dogs. A reversible snare was placed on the left anterior descending coronary artery; regional myocardial perfusion was continuously measured using the short-lived isotope krypton-81m, and myocardial metabolism was assessed using the epicardial electrocardiogram and measurement of release of creatine kinase activity from the affected segment of myocardium. Six dogs with no arterial occlusion acted as “sham operated” dogs; six others in which the snare was occluded acted as a control group and a third group of six were given propranolol, 0.5 mg/kg, 30 minutes after coronary occlusion. All variables were recorded before and for 5 hours after coronary occlusion. Dogs treated with propranolol showed a significant improvement in regional myocardial perfusion to the affected segment, decreased loss of electrically active myocardium at the end of each experiment for any given degree of early S-T segment elevation and a delay in the local release of creatine kinase activity compared with that in the control dogs. These results suggest that propranolol exerts a beneficial effect on the progress of ischemic myocardial damage when given shortly after the onset of infarction. |
| Databáze: | OpenAIRE |
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