REM sleep deprivation impairs muscle regeneration in rats
| Autor: | Sergio Tufik, Marco Túlio de Mello, Marcos Mônico-Neto, Hanna Karen Moreira Antunes, Kil Sun Lee, Murilo Dáttilo, Daniel Araki Ribeiro |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Clinical Biochemistry Connective tissue Sleep REM Biology 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Endocrinology Internal medicine Rem sleep deprivation medicine Animals Regeneration Insulin-Like Growth Factor I Rats Wistar Muscle Skeletal Skeletal muscle Cell Biology Muscle injury Sleep in non-human animals Surgery Rats Muscle regeneration Sleep deprivation 030104 developmental biology medicine.anatomical_structure Sleep Deprivation medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | Growth factors (Chur, Switzerland). 35(1) |
| ISSN: | 1029-2292 |
| Popis: | Introduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion.Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery.Results: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers.Conclusions: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration. |
| Databáze: | OpenAIRE |
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