The Effect of Anticoagulants on the Distribution of Chromium VI in Blood Fractions
| Autor: | G.A. Afolaranmi, R. M. Dominic Meek, M. Helen Grant, Justice N. A. Tettey, H.M. Murray |
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| Rok vydání: | 2010 |
| Předmět: |
Chromium
inorganic chemicals Erythrocytes medicine.drug_class Metal ions in aqueous solution chemistry.chemical_element In Vitro Techniques Sodium Citrate Plasma chemistry.chemical_compound In vivo Sodium citrate medicine Humans Orthopedics and Sports Medicine Citrates Hexavalent chromium Edetic Acid Chromatography Heparin business.industry Anticoagulant Anticoagulants In vitro chemistry Immunology Chromium Alloys Hip Prosthesis business Cobalt |
| Zdroj: | The Journal of Arthroplasty. 25:118-120 |
| ISSN: | 0883-5403 |
| DOI: | 10.1016/j.arth.2008.10.012 |
| Popis: | Metal-on-metal resurfacing arthroplasty is associated with elevated circulating levels of cobalt and chromium ions. To establish the long-term safety of metal-on-metal resurfacing arthroplasty, it has been recommended that during clinical follow-up of these patients, the levels of these metal ions in blood be monitored. In this article, we provide information on the distribution of chromium VI ions (the predominant form of chromium released by cobalt-chrome alloys in vivo and in vitro) in blood fractions. Chromium VI is predominantly partitioned into red blood cells compared with plasma (analysis of variance, P < .05). The extent of accumulation in red blood cells is influenced by the anticoagulant used to collect the blood, with EDTA giving a lower partitioning into red cells compared with sodium citrate and sodium heparin. |
| Databáze: | OpenAIRE |
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