Usefulness of a short femur in the in utero detection of skeletal dysplasias

Autor:	Donald G. Mitchell, Rick I. Feld, Laurence Needleman, L Blum, Kathleen Kuhlman, Sharon R. Segal, Ronald J. Wapner, P L Hilpert, P N Burns, Alfred B. Kurtz
Rok vydání:	1990
Předmět:	Bone Diseases Developmental Fetus Pregnancy business.industry Radiography Gestational age Prenatal diagnosis Anatomy medicine.disease Fetal Diseases In utero Prenatal Diagnosis Humans Medicine Female Radiology Nuclear Medicine and imaging Femur business Short femur
Zdroj:	Radiology. 177:197-200
ISSN:	1527-1315 0033-8419
Popis:	In 28 fetuses studied during a 4 1/2-year period, the initial femur was below 2 standard deviations (SDs) of the mean when compared with the biparietal diameter. These fetuses were considered at risk for skeletal dysplasias and were followed up. Studies were performed at a mean gestational age of 26.7 weeks (range, 15.3-41.0 weeks). Group 1 had a femur length 1-4 mm below the 2-SDs line (range, -2.0 to -4.0 SDs); no other abnormalities were detected. Interval examination of 12 femurs showed that 10 either remained shortened to the same degree or had a growth spurt. At birth, all subjects were healthy except one with mild growth retardation and one with a chromosomal abnormality. Of the two subjects that failed to continue normal growth, one was healthy and the other was a heterozygous achondroplastic dwarf. Group 2 had greater femoral shortness; all measurements were more than 5 mm below the 2-SD line (range, -4.3 to -31.0 SDs). All had fetal abnormalities and significant skeletal dysplasias. The authors conclude that the number of millimeters below the 2-SDs line is an accurate, easy criterion for evaluation of femoral length.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278dfffc582e2d8eb045566aa43174ea https://doi.org/10.1148/radiology.177.1.2399317 Zobrazit plný text záznamu