Knoevenagel Adducts as Trimethylenemethane Dipole Surrogates
| Autor: | Primali V. Navaratne, Alexander J. Grenning, Peter Vertesaljai |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
inorganic chemicals
010405 organic chemistry Chemistry Trimethylenemethane chemistry.chemical_element General Chemistry General Medicine Malonic acid 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis 0104 chemical sciences Adduct chemistry.chemical_compound Tsuji–Trost reaction Organic chemistry Knoevenagel condensation Palladium |
| Zdroj: | Angewandte Chemie (International ed. in English). 55(1) |
| ISSN: | 1521-3773 |
| Popis: | Knoevenagel adducts derived from readily available acetoxyacetone and malonic acid derivatives served as trimethylenemethane surrogates for formal 1,3-difunctionalization through a sequence of selective γ-deprotonation/α-alkylation and palladium(0)-catalyzed allylic alkylation. Herein, we report the discovery and development of a three-component 1,3-difunctionalization of Knoevenagel adducts as well as a unique palladium(0)-catalyzed branch-selective allylic alkylation. |
| Databáze: | OpenAIRE |
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