Oligodendrocyte ablation affects the coordinated interaction between granule and Purkinje neurons during cerebellum development
| Autor: | Martial Ruat, Sandrine Doretto, Ludovic Collin, Monica Malerba, Emiliana Borrelli |
|---|---|
| Přispěvatelé: | Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, Department of Psychiatry and Human Behavior, Gillespie Neuroscience Research Facility-University of California [Irvine] (UCI), University of California-University of California, Laboratoire de neurobiologie cellulaire et moléculaire (NBCM), Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie Alfred Fessard (INAF), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
MESH: Signal Transduction MESH: Extracellular Matrix Proteins Cerebellum MESH: Myelin Sheath MESH: Neurons Cell Communication MESH: Brain-Derived Neurotrophic Factor Mice Myelin Granule neurons 0302 clinical medicine Transgenic mice MESH: Animals Reelin MESH: Nerve Tissue Proteins MESH: Serine Endopeptidases Sonic hedgehog Myelin Sheath MESH: Cell Adhesion Molecules Neuronal Neurons Extracellular Matrix Proteins 0303 health sciences biology Oligodendrocytes Serine Endopeptidases MESH: Receptor trkA MESH: Oligodendroglia Anatomy Cell biology Oligodendroglia medicine.anatomical_structure Purkinje cells [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Signal Transduction MESH: Thymidine Kinase Cell type MESH: Mice Transgenic Cell Adhesion Molecules Neuronal Central nervous system Mice Transgenic Nerve Tissue Proteins Thymidine Kinase 03 medical and health sciences Cerebellum development MESH: Purkinje Cells MESH: Cell Communication medicine Animals Humans Hedgehog Proteins Receptor trkA MESH: Mice 030304 developmental biology Brain-derived neurotrophic factor MESH: Humans Brain-Derived Neurotrophic Factor Cell Biology MESH: Hedgehog Proteins Oligodendrocyte MESH: Cerebellum MESH: Male Reelin Protein nervous system biology.protein 030217 neurology & neurosurgery |
| Zdroj: | Experimental Cell Research Experimental Cell Research, Elsevier, 2007, 313 (13), pp.2946-57. ⟨10.1016/j.yexcr.2007.05.003⟩ |
| ISSN: | 0014-4827 1090-2422 |
| DOI: | 10.1016/j.yexcr.2007.05.003⟩ |
| Popis: | Oligodendrocytes (OLs) are the glial cells of the central nervous system (CNS) classically known to be devoted to the formation of myelin sheaths around most axons of the vertebrate brain. We have addressed the role of these cells during cerebellar development, by ablating OLs in vivo. Previous analyses had indicated that OL ablation during the first six postnatal days results into a striking cerebellar phenotype, whose major features are a strong reduction of granule neurons and aberrant Purkinje cells development. These two cell types are highly interconnected during cerebellar development through the production of molecules that help their proliferation, differentiation and maintenance. In this article, we present data showing that OL ablation has major effects on the physiology of Purkinje (PC) and granule cells (GC). In particular, OL ablation results into a reduction of sonic hedgehog (Shh), Brain Derived Neurotrophic Factor (BDNF), and Reelin (Rln) expression. These results indicate that absence of OLs profoundly alters the normal cerebellar developmental program. |
| Databáze: | OpenAIRE |
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