Cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives as antioxidants against light-induced retinal degeneration
| Autor: | Grégory Durand, Isabelle Ranchon-Cole, Fanny Choteau, C. Cercy, Bernard Pucci |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Retinal degeneration
Antioxidant Light Stereochemistry medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Disaccharides medicine.disease_cause Biochemistry Antioxidants Nitrone Cyclic N-Oxides chemistry.chemical_compound Retinal Diseases Drug Discovery medicine Animals Molecular Biology chemistry.chemical_classification Reactive oxygen species Retina Retinal Degeneration Organic Chemistry Biological activity Retinal medicine.disease Rats Cholesterol medicine.anatomical_structure chemistry Molecular Medicine Imines Reactive Oxygen Species Oxidative stress |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 20:7405-7409 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2010.10.037 |
| Popis: | Two cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives were synthesized as antioxidants against light-induced retinal degeneration. Whereas nitrone 10 significantly protected retina against bright fluorescent light exposure when injected into the vitreous at 1 mM, no protection was observed with nitrone 6. The parent compound α-phenyl-N-tert-butyl nitrone also exhibited protective activity at 9 mM but not at 1 mM. This suggests that nitrone 10 may be a candidate for the treatment of retinal diseases. |
| Databáze: | OpenAIRE |
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