Imaging Studies of Patients with Malignant Fibrous Histiocytoma Using C-11-Alpha-Aminoisobutyric Acid (AIB)
| Autor: | Dahl, Pat Zanzonico, Richard S. Benua, R. Lee, Robert E. Reiman, S. D. J. Yeh, Peter S. Conti, John S. Laughlin, R.E. Bigler, B. Schmall |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Aminoisobutyric Acids medicine.medical_treatment Gallium Radioisotopes Technetium Tc 99m Medronate Gamma scintigraphy In vivo Humans Medicine Radiology Nuclear Medicine and imaging In patient Carbon Radioisotopes Radionuclide Imaging chemistry.chemical_classification Chemotherapy Histiocytoma Benign Fibrous business.industry Femoral Neoplasms Cancer General Medicine Middle Aged Thoracic Neoplasms medicine.disease Amino acid Alpha-aminoisobutyric acid chemistry Female Sarcoma business |
| Zdroj: | Clinical Nuclear Medicine. 12:22-26 |
| ISSN: | 0363-9762 |
| DOI: | 10.1097/00003072-198701000-00005 |
| Popis: | Alpha-aminoisobutyric acid (AIB), a synthetic, nonmetabolized amino acid which is rapidly transported into viable cells by the A-type or alanine-preferring amino acid transport system, has been labeled with the short-lived, positron-emitting radionuclide carbon-11. Carbon-11 labeled AIB is currently being evaluated as a tumor imaging agent for in vivo amino acid transport studies in patients with cancer. In this study, C-11 AIB was used to image two patients with malignant fibrous histiocytoma (MFH), a pleomorphic sarcoma. Following intravenous administration of C-11 AIB, tumors in the distal femur of one patient and in the anterior chest wall of another patient were well visualized using high energy gamma scintigraphy. Since therapy may alter the accumulation of amino acids in tumor tissue, studies using C-11 AIB in patients with MFH before and after chemotherapy are in progress. |
| Databáze: | OpenAIRE |
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