Hydroperoxide-Reducing Enzymes in the Regulation of Free-Radical Processes
| Autor: | Sergey V. Gudkov, Mars G. Sharapov, Vadim Z. Lankin |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Biochemistry (Moscow). 86:1256-1274 |
| ISSN: | 1608-3040 0006-2979 |
| DOI: | 10.1134/s0006297921100084 |
| Popis: | The review presents current concepts of the molecular mechanisms of oxidative stress development and describes main stages of the free-radical reactions in oxidative stress. Endogenous and exogenous factors of the oxidative stress development, including dysfunction of cell oxidoreductase systems, as well as the effects of various external physicochemical factors, are discussed. The review also describes the main components of the antioxidant defense system and stages of its evolution, with a special focus on peroxiredoxins, glutathione peroxidases, and glutathione S-transferases, which share some phylogenetic, structural, and catalytic properties. The substrate specificity, as well as the similarities and differences in the catalytic mechanisms of these enzymes, are discussed in detail. The role of peroxiredoxins, glutathione peroxidases, and glutathione S-transferases in the regulation of hydroperoxide-mediated intracellular and intercellular signaling and interactions of these enzymes with receptors and non-receptor proteins are described. An important contribution of hydroperoxide-reducing enzymes to the antioxidant protection and regulation of such cell processes as growth, differentiation, and apoptosis is demonstrated. |
| Databáze: | OpenAIRE |
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