Whole Exome Sequencing reveals new candidate genes in host genomic susceptibility to Respiratory Syncytial Virus Disease
| Autor: | Jacobo Pardo-Seco, Laura Moreno-Galarraga, Rosaura Leis, Lorenzo Redondo Collazo, Sara Pischedda, Ignacio Oulego-Erroz, Jorge Amigo, MARIA LUZ GARCIA-GARCIA, Pablo Obando-Pacheco, Cristina Calvo, Federico Martinon-Torres, Irene Rivero Calle, Ruth Barral Arca, Jose Gómez Rial, Beatriz Morillo Gutierrez, Alberto Gómez-Carballa, María José Currás Tuala, Antonio Salas, Máximo Fraga Rodríguez, Miriam Cebey-López |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Candidate gene lcsh:Medicine Respiratory Syncytial Virus Infections Biology Genome Polymorphism Single Nucleotide Virus Article Whole Exome Sequencing 03 medical and health sciences 0302 clinical medicine Exome Sequencing medicine Humans Genetic Predisposition to Disease 1000 Genomes Project lcsh:Science Gene Exome Exome sequencing Genetic Association Studies Genetics Multidisciplinary Genome Human lcsh:R Infant Newborn Infant medicine.disease Virology 030104 developmental biology Gene Ontology Bronchiolitis Case-Control Studies Respiratory Syncytial Virus Human Host-Pathogen Interactions lcsh:Q 030217 neurology & neurosurgery |
| Zdroj: | Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017) |
| Popis: | Respiratory syncytial virus (RSV) is an important cause of serious lower respiratory tract disease in infants. Several studies have shown evidence pointing to the genome of the host as an important factor determining susceptibility to respiratory disease caused by RSV. We sequenced the complete exomes of 54 patients infected by RSV that needed hospitalization due to development of severe bronchiolitis. The Iberian sample (IBS) from The 1000 Genomes Project (1000G) was used as control group; all the association results were pseudo-replicated using other 1000G-European controls and Spanish controls. The study points to SNP rs199665292 in the olfactory receptor (OR) gene OR13C5 as the best candidate variant (P-value = 1.16 × 10−12; OR = 5.56). Genetic variants at HLA genes (HLA-DQA1, HLA-DPB1), and in the mucin 4 gene (MUC4) also emerge as susceptibility candidates. By collapsing rare variants in genes and weighing by pathogenicity, we obtained confirmatory signals of association in the OR gene OR8U1/OR8U8, the taste receptor TAS2R19, and another mucin gene (MUC6). Overall, we identified new predisposition variants and genes related to RSV infection. Of special interest is the association of RSV to olfactory and taste receptors; this finding is in line with recent evidence pointing to their role in viral infectious diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|