Lanomycin and glucolanomycin, antifungal agents produced by Pycnidiophora dispersa. II. Structure elucidation
| Autor: | Mark S. Bolgar, Alicia D. Kahle, Douglas W. Phillipson, Joseph O'sullivan, Janice H. Johnson |
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| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Antifungal Antifungal Agents Stereochemistry medicine.drug_class Molecular Conformation Pycnidiophora dispersa Ring (chemistry) In vitro Anti-Bacterial Agents chemistry.chemical_compound Aminoglycosides Ascomycota chemistry Pyran Drug Discovery Glycine medicine Molecule Chemical decomposition Pyrans |
| Zdroj: | The Journal of Antibiotics. 45:313-319 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | Two novel antifungal agents, lanomycin and glucolanomycin, as well as a biologically inactive degradation product, lanomycinol, were isolated from liquid fermentations of Pycnidiophora dispersa. All three compounds share an E,E,E-triene appended to a pyran ring. Lanomycin contains a glycine ester and glucolanomycin possesses a glucose unit attached to the glycine nitrogen. The structures, including absolute stereochemistry, were determined by spectroscopic analysis and partial chemical degradation. Both of the glycine containing compounds show activity against several pathogenic fungi in vitro. |
| Databáze: | OpenAIRE |
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