Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers
| Autor: | Marta Rubio-Camacho, Maria José Martínez-Tomé, Amalia Mira, Ricardo Mallavia, Carmen Reyes Mateo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Methyl Ethers
Vinyl Compounds Polymers QH301-705.5 Color PMVEMA Methyl vinyl ether doxorubicin Catalysis Article Inorganic Chemistry chemistry.chemical_compound nanogels fluorescent conjugated polymers Zeta potential Fluorescence Resonance Energy Transfer Humans Physical and Theoretical Chemistry Particle Size bioimaging Biology (General) Molecular Biology QD1-999 Spectroscopy Maleic Anhydrides Drug Carriers Fluorenes Antibiotics Antineoplastic Chemistry Organic Chemistry Esters General Medicine Hydrogen-Ion Concentration Fluorescence Conjugated Polyelectrolytes Polyelectrolyte Computer Science Applications drug-delivery Ionic strength Self-healing hydrogels Polyvinyls nanoparticles Drug carrier Nuclear chemistry |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 9607, p 9607 (2021) International Journal of Molecular Sciences Volume 22 Issue 17 |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | In this study, we employed the copolymer poly(methyl vinyl ether-alt-maleic monoethyl ester) (PMVEMA-Es) and three fluorene-based cationic conjugated polyelectrolytes to develop fluorescent nanoparticles with emission in the blue, green and red spectral regions. The size, Zeta Potential, polydispersity, morphology, time-stability and fluorescent properties of these nanoparticles were characterized, as well as the nature of the interaction between both PMVEMA-Es and fluorescent polyelectrolytes. Because PMVEMA-Es contains a carboxylic acid group in its structure, the effects of pH and ionic strength on the nanoparticles were also evaluated, finding that the size is responsive to pH and ionic strength, largely swelling at physiological pH and returning to their initial size at acidic pHs. Thus, the developed fluorescent nanoparticles can be categorized as pH-sensitive fluorescent nanogels, since they possess the properties of both pH-responsive hydrogels and nanoparticulate systems. Doxorubicin (DOX) was used as a model drug to show the capacity of the blue-emitting nanogels to hold drugs in acidic media and release them at physiological pH, from changes in the fluorescence properties of both nanoparticles and DOX. In addition, preliminary studies by super-resolution confocal microscopy were performed, regarding their potential use as image probes. |
| Databáze: | OpenAIRE |
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