The Expression of T Cell Related Costimulatory Molecules in Multiple Myeloma

Autor:	E. Yuen, D. E. Joshua, Ross D. Brown, John Gibson, Belinda Pope
Rok vydání:	1998
Předmět:	Cancer Research Immunoconjugates T-Lymphocytes T cell Antigen presentation Abatacept Immune system CD28 Antigens Antigens CD Antigens Neoplasm medicine Humans CTLA-4 Antigen CD86 Antigen Presentation CD40 biology CD28 Hematology Antigens Differentiation Molecular biology medicine.anatomical_structure Oncology Immunology biology.protein Multiple Myeloma CD80 CD8
Zdroj:	Leukemia & Lymphoma. 31:379-384
ISSN:	1029-2403 1042-8194
DOI:	10.3109/10428199809059231
Popis:	Presentation of tumour antigen by malignant cells not expressing costimulatory molecules is considered to be a major cause of the failure of the host's immune response against tumours. This study has determined the expression of the B7 family of costimulatory molecules on malignant plasma cells and the expression of the counter receptor molecules, CD28 and CD152 (CTLA-4), on T cells of patients with multiple myeloma. CD28 expression was present on most CD4 cells but was lower on CD8 cells especially from those patients who also showed evidence of expanded T cell clones (median 40%. z=2.4; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278702a5b388efb693bbb91d1937c02c https://doi.org/10.3109/10428199809059231 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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