Insulin-like factor 3 levels in amniotic fluid of human male fetuses
| Autor: | Richard Ivell, Ravinder Anand-Ivell, Deborah A. Driscoll, Jeanne Manson |
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| Přispěvatelé: | Anand-Ivell, Jit Kaur, Ivell, Richard, Driscoll, Deborah, Manson, Jeanne |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Sex Determination Analysis Amniotic fluid Clinical Sciences Population Physiology Gestational Age Preeclampsia Cohort Studies Fetus Pre-Eclampsia Pregnancy medicine Humans Insulin Testosterone education Retrospective Studies Immunoassay education.field_of_study medicine.diagnostic_test business.industry Obstetrics Rehabilitation Obstetrics and Gynecology Gestational age Proteins medicine.disease Amniotic Fluid Reproductive Medicine Pregnancy Trimester Second Amniocentesis Gestation Regression Analysis Female business |
| Zdroj: | Human reproduction (Oxford, England). 23(5) |
| ISSN: | 1460-2350 |
| Popis: | Background Rodent studies suggest that the peptide hormone insulin-like factor 3 (Insl3) made by the fetal testis is responsible for the first transabdominal phase of testicular descent, and may be affected by xenobiotics to disrupt male reproductive tract development. To date, there is very little information on the production of INSL3 by the human fetus during gestation. The objective of the present study was to determine the concentrations and time course during pregnancy of INSL3 and testosterone production in human fetuses and their associations with maternal characteristics, pregnancy complications and outcome. Methods This is a retrospective cohort study in which women who contributed amniotic fluid specimens to a bank from 2003-2006 were followed to determine their pregnancy complications and pregnancy outcome. Amniotic fluid specimens were collected from the Reproductive Genetics Laboratory of the Hospital of the University of Pennsylvania subsequent to routine amniocentesis. INSL3 and total testosterone levels were measured in amniotic fluid (from n = 50 female, n = 237 male fetuses) by validated immunoassays and correlated with maternal characteristics, pregnancy complications and outcomes. Results INSL3 was only detectable in amniotic fluid from male fetuses, and highest levels occurred from weeks 15-17 of gestation. INSL3 concentration was positively associated with increased birth weight, the occurrence of pre-eclampsia and advanced maternal age, but not with testosterone levels. Conclusions INSL3 concentration in human amniotic fluid is potentially predictive of fetal sex and pre-eclampsia, and presumably reflects the functioning of the fetal Leydig cell population. |
| Databáze: | OpenAIRE |
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