Isolation and structures of an antifungal antibiotic, fusarielin A, and related compounds produced by a Fusarium sp
| Autor: | Shigeo Iwasaki, Rie Sunaga, Kazuo Furihata, Naoko Morisaki, Hisayoshi Kobayashi |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Fusarium
Antifungal Agents Magnetic Resonance Spectroscopy Chemical Phenomena Stereochemistry Swine Molecular Conformation Naphthalenes Absolute structure Drug Discovery Animals Humans Spectral data Pharmacology Carbon Isotopes biology Antifungal antibiotic Chemistry Physical Fungi Stereoisomerism biology.organism_classification Nmr data Microtubule Proteins Epoxy Compounds Protons Chirality (chemistry) HeLa Cells |
| Zdroj: | The Journal of antibiotics. 48(1) |
| ISSN: | 0021-8820 |
| Popis: | A new antifungal antibiotic, fusarielin A, and three related compounds, fusarielins B, C and D, were obtained from a culture of a Fusarium sp. The skeletal structure and the relative stereochemistry of fusarielin A were determined mainly on the basis of its NMR data, and the absolute structure was elucidated by using the exciton chirality method and the modified Mosher method. The structures of the other homologues were determined by comparison of their spectral data with those of fusarielin A. |
| Databáze: | OpenAIRE |
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