Late Effects of Radiation on the Central Nervous System: Role of Vascular Endothelial Damage and Glial Stem Cell Survival
| Autor: | Peggy L. Micca, Jeffrey A. Coderre, Albert J. van der Kogel, John W. Hopewell, G. M. Morris, Ilja Verhagen, B.J. Kleiboer |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cell Survival Biophysics Biology Radiation Dosage Spinal Cord Diseases Myelopathy Translational research [ONCOL 3] Interventional oncology [UMCN 1.5] Parenchyma medicine Animals Radiology Nuclear Medicine and imaging Progenitor cell Radiation Injuries Clonogenic assay Cells Cultured Radiation Dose-Response Relationship Radiation medicine.disease Rats Inbred F344 Rats Endothelial stem cell Dose–response relationship medicine.anatomical_structure Spinal Cord Immunology Endothelium Vascular Stem cell Neuroglia Astrocyte |
| Zdroj: | Radiation Research, 166, 3, pp. 495-503 Radiation Research, 166, 495-503 |
| ISSN: | 1938-5404 0033-7587 |
| Popis: | Item does not contain fulltext Selective irradiation of the vasculature of the rat spinal cord was used in this study, which was designed specifically to address the question as to whether it is the endothelial cell or the glial progenitor cell that is the target responsible for late white matter necrosis in the CNS. Selective irradiation of the vascular endothelium was achieved by the intraperitoneal (ip) administration of a boron compound known as BSH (Na(2)B(12)H(11)SH), followed by local irradiation with thermal neutrons. The blood-brain barrier is known to exclude BSH from the CNS parenchyma. Thirty minutes after the ip injection of BSH, the boron concentration in blood was 100 microg (10)B/ g, while that in the CNS parenchyma was below the detection limit of the boron analysis system |
| Databáze: | OpenAIRE |
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