Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: rare T-cell receptor gene rearrangements are associated with poor outcome

Autor: Karrman, Kristina, Forestier, Erik, Heyman, Mats, Andersen, Mette K, Autio, Kirsi, Blennow, Elisabeth, Borgström, Georg, Ehrencrona, Hans, Golovleva, Irina, Heim, Sverre, Heinonen, Kristiina, Hovland, Randi, Johannsson, Johann H, Kerndrup, Gitte, Nordgren, Ann, Palmqvist, Lars, Johansson, Bertil, Nordic Society of, Pediatric Hematology, Oncology, Swedish, Cytogenetic Leukemia Study Group, NOPHO, Leukemia Cytogenetic Study Group
Rok vydání: 2009
Předmět:
Zdroj: Karrman, K, Forestier, E, Heyman, M, Andersen, M K, Autio, K, Blennow, E, Borgström, G, Ehrencrona, H, Golovleva, I, Heim, S, Heinonen, K, Hovland, R, Johannsson, J H, Kerndrup, G, Nordgren, A, Palmqvist, L, Johansson, B, Nordic Society of, P H O, Swedish, C L S G & NOPHO, L C S G 2009, ' Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: rare T-cell receptor gene rearrangements are associated with poor outcome ', Genes, Chromosomes & Cancer, vol. 48, no. 9, pp. 795-805 . https://doi.org/10.1002/gcc.20684
ISSN: 1098-2264
Popis: Udgivelsesdato: 2009-Sep Clinical characteristics and cytogenetic aberrations were ascertained and reviewed in a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias (T-ALLs) diagnosed between 1992 and 2006 in the Nordic countries. Informative karyotypic results were obtained in 249 (87%) cases, of which 119 (48%) were cytogenetically abnormal. Most (62%) of the aberrant T-ALLs were pseudodiploid. Structural changes were more common than numerical ones; 86% displayed at least one structural abnormality and 41% at least one numerical anomaly. The most frequent abnormalities were T-cell receptor (TCR) gene rearrangements (20%) [TCR;11p13 (10%), TCR;10q24 (3%), TCR;other (8%)], del(9p) (17%), +8 (14%), del(6q) (12%), and 11q23 rearrangements (6%). The TCR;other group comprised the rare rearrangements t(X;14)(p11;q11), t(X;7)(q22;q34), t(1;14)(p32;q11), ins(14;5)(q11;q?q?), inv(7)(p15q34), t(8;14)(q24;q11), t(7;11)(q34;p15), and t(12;14)(p13;q11). The clinical characteristics of this Nordic patient cohort agreed well with previous larger series, with a median age of 9.0 years, male predominance (male/female ratio 3.1), median white blood cell (WBC) count of 66.5 x 10(9)/l, and a high incidence of mediastinal mass and central nervous system involvement (59% and 9.5%, respectively). These features did not differ significantly among the various genetic subgroups. 5-year event-free survival (EFS) and overall survival for all patients were 0.61 (+/-0.03) and 0.67 (+/-0.03), respectively. In a multivariate analysis, two factors affected negatively the EFS, namely a WBC count of > or =200 x 10(9)/l (P < 0.001) and the presence of rare TCR rearrangements (P = 0.001). In conclusion, in this large series of childhood T-ALLs from the Nordic countries, the cytogenetic findings were not associated with risk of therapy failure with the exception of the TCR;other group. However, further prospective and collaborative investigations of this genetically heterogeneous entity are needed to confirm these results.
Databáze: OpenAIRE
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