Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning
| Autor: | Pavel Zidek, Ctirad Sedlak, Miroslav Mazur, Darren M. Roberts, Sergey Zakharov, Tomáš Šálek, Michal Pisar, Daniela Pelclova, Josef Chalupa, Jan Smid, Kamil Kodras, Jaromir Belacek, Zdenek Belik, Knut Erik Hovda, Viktor Talafa, Jiri Leps, Jiri Latta, Cyril Kucera, Tomas Navratil, Jan Rulisek, Robert Bocek, Michal Senkyrik, Daniel Nalos |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent medicine.medical_treatment Toxicology Cohort Studies 03 medical and health sciences 0302 clinical medicine Renal Dialysis Internal medicine medicine Humans Arterial pH Renal replacement therapy Aged business.industry Methanol 030208 emergency & critical care medicine Metabolic acidosis General Medicine Hydrogen-Ion Concentration Middle Aged Prognosis medicine.disease Surgery Intermittent hemodialysis Continuous hemodialysis Renal Replacement Therapy Bicarbonates Methanol poisoning Acute Disease Cardiology Arterial blood Female Acidosis business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Clinical Toxicology. 55:123-132 |
| ISSN: | 1556-9519 1556-3650 |
| Popis: | Context: Acidemia is a marker of prognosis in methanol poisoning, as well as compounding formate-induced cytotoxicity. Prompt correction of acidemia is a key treatment of methanol toxicity and methods to optimize this are poorly defined.Objective: We studied the efficiency of acidemia correction by intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) in a mass outbreak of methanol poisoning.Methods: The study was designed as observational cohort study. The mean time for an increase of 1 mmol/L HCO3–, 0.01 unit arterial blood pH, and the total time for correction of HCO3– were determined in IHD- and CRRT-treated patients.Results: Data were obtained from 18 patients treated with IHD and 13 patients treated with CRRT. At baseline, CRRT group was more acidemic than IHD group (mean arterial pH 6.79 ± 0.10 versus 7.05 ± 0.10; p = 0.001). No association was found between the rate of acidemia correction and age, weight, serum methanol, lactate, formate, and glucose on admission.... |
| Databáze: | OpenAIRE |
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