Deliberate self-poisoning with tiagabine: an unusual toxidrome
| Autor: | Harish Kalra, Frank Daly, L. Peter Hackett, Richard A Forbes |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Hypersalivation
Adult Tiagabine medicine.medical_treatment Nipecotic Acids Poison control Suicide Attempted medicine Humans Glasgow Coma Scale Toxidrome business.industry Delirium medicine.disease Anticonvulsant Anesthesia Emergency Medicine Vomiting Anticonvulsants Female medicine.symptom business Myoclonus medicine.drug |
| Zdroj: | Emergency medicine Australasia : EMA. 19(6) |
| ISSN: | 1742-6731 |
| Popis: | Tiagabine is an anticonvulsant acting by selective inhibition of neuronal and glial gamma-aminobutyric acid uptake, resulting in increased gamma-aminobutyric acid-mediated inhibition in the brain. Few reports in the literature describe the clinical course of severe tiagabine intoxication. A 44-year-old woman presented after deliberate self-poisoning with 100 tiagabine 15 mg tablets (1,500 mg; 25 mg/kg). Serum tiagabine level was 4,600 microg/L (1,725 mmol/L) at presentation, 20 times levels associated with therapeutic dosing. Intoxication was manifested by profuse vomiting, coma, myoclonus, generalized rigidity, bradycardia, hypertension, hypersalivation and generalized piloerection within 2 h of ingestion. The patient was intubated and management was supportive. Coma lasted until 10 h post-ingestion, but recovery was complicated by severe agitated delirium lasting 12 h. The patient recovered fully within 26 h of ingestion. Tiagabine deliberate self-poisoning was associated with the rapid onset of coma and an unusual toxidrome. Recovery, although complicated by agitated delirium, was complete within 26 h. |
| Databáze: | OpenAIRE |
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