Multiomics uncovers developing immunological lineages in human
| Autor: | Simone Webb, Muzlifah Haniffa, Emily Stephenson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Epigenomics
Proteomics 0301 basic medicine Immunology Embryonic Development 50th Anniversary Reviews Computational biology Biology Limited access 03 medical and health sciences 0302 clinical medicine Humans Immunology and Allergy Cell Lineage developmental immunology Basic Modalities Gene Expression Profiling Critical question High-Throughput Nucleotide Sequencing Experimental Animal Models Genomics bioinformatics Embryo Mammalian Biobank Human development (humanity) 3. Good health Highlights 030104 developmental biology prenatal immunity Review|Basic Multi omics Single-Cell Analysis Developmental tissue 030215 immunology |
| Zdroj: | European Journal of Immunology |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.202048769 |
| Popis: | The development of the human immune system during embryonic and fetal life has historically been difficult to research due to limited access to human tissue. Experimental animal models have been widely used to study development but cellular and molecular programmes may not be conserved across species. The advent of multiomic single‐cell technologies and an increase in human developmental tissue biobank resources have facilitated single‐cell multiomic studies focused on human immune development. A critical question in the near future is "How do we best reconcile scientific findings across multiple omic modalities, developmental time, and organismic space?" In this review, we discuss the application of single‐cell multiomic technologies to unravel the major cellular lineages in the prenatal human immune system. We also identify key areas where the combined power of multiomics technologies can be leveraged to address specific immunological gaps in our current knowledge and explore new research horizons in human development. Recent advances in developmental immunology have been driven by improvements in single cell multi omic technologies, integrative bioinformatic analysis tools, and global consortia efforts. Herein, we detail these advances, which pave way for a deeper understanding of prenatal immunity and the genetic perturbations that drive disease during prenatal development. Illustration created with BioRender.com. |
| Databáze: | OpenAIRE |
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