IL28B polymorphisms determine early viral kinetics and treatment outcome in patients receiving peginterferon/ribavirin for chronic hepatitis C genotype 1

Autor:	Martin Lagging, Rune Wejstål, Johan Westin, Staffan Nilsson, Anders Eilard, Gunnar Norkrans, Jonas Söderholm, Magnus Lindh, Birgitta Arnholm, Kristoffer Hellstrand, Thomas Wahlberg
Rok vydání:	2011
Předmět:	Adult Male medicine.medical_specialty Genotype Hepacivirus Alpha interferon Single-nucleotide polymorphism Antiviral Agents Polymorphism Single Nucleotide Gastroenterology Linkage Disequilibrium Virus Polyethylene Glycols chemistry.chemical_compound Virology Internal medicine Ribavirin medicine Humans Hepatology biology Interleukins Interferon-alpha virus diseases Hepatitis C Hepatitis C Chronic Middle Aged Prognosis medicine.disease biology.organism_classification Recombinant Proteins digestive system diseases Kinetics Treatment Outcome Infectious Diseases chemistry Immunology Female Interferons Viral load
Zdroj:	Journal of Viral Hepatitis. 18
ISSN:	1365-2893 1352-0504
DOI:	10.1111/j.1365-2893.2010.01425.x
Popis:	Single nucleotide polymorphisms (SNPs) upstream of IL28B predict the outcome of treatment in chronic hepatitis C virus (HCV) infection, but their impact on viral kinetics and relation to other predictors are not well known. Here, two SNPs, rs12979860 and rs8099917, were analysed and related to early viral kinetics during treatment in 110 patients with HCV genotype 1 infection. The reduction of HCV RNA after 7 days of therapy was more pronounced (P
Databáze:	OpenAIRE
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