Formaldehyde Dose-Response in Healthy Nonsmokers
| Autor: | Larry R. Sauder, J. Richard Hebel, Donald J. Green, Marie Chatham, Thomas J. Kulle |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Atmospheric Science Environmental Engineering Formaldehyde Physiology medicine.disease_cause Pulmonary function testing Toxicology chemistry.chemical_compound FEV1/FVC ratio medicine Humans Respiratory system General Environmental Science General Engineering Pollution Respiratory Function Tests medicine.anatomical_structure chemistry Odor Irritants General Earth and Planetary Sciences Female Bronchoconstriction Maximum Allowable Concentration medicine.symptom Irritation Respiratory tract |
| Zdroj: | JAPCA. 37:919-924 |
| ISSN: | 0894-0630 |
| DOI: | 10.1080/08940630.1987.10466285 |
| Popis: | Industrial, commercial, and domestic levels of formaldehyde exposure range from 5.0 ppm. Irritation of the eyes and upper respiratory tract predominate, and bronchoconstriction is described in case reports. However, pulmonary function and irritant symptoms together have not been assessed over a range of HCHO concentrations in a controlled environment. We investigated dose response in both symptoms and pulmonary function associated with 3-h exposures to 0.0-3.0 ppm HCHO in a controlled environmental chamber. Ten subjects were randomly exposed to 0.0, 0.5, 1.0, and 2.0 ppm HCHO at rest plus 2.0 ppm HCHO with exercise and nine additional subjects were randomly exposed to 0.0,1.0,2.0, and 3.0 ppm HCHO at rest plus 2.0 ppm HCHO with exercise. Significant dose-response relationships in odor and eye irritation were observed (p < 0.05). Nasal flow resistance was increased at 3.0 ppm (p < 0.01), but not at 2.0 ppm HCHO. There were no significant decrements in pulmonary function (FVC, FEV1, FEF25-75%, SGaw... |
| Databáze: | OpenAIRE |
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