'A surviving myth' – corticosteroids are still considered ulcerogenic by a majority of physicians
| Autor: | Ondrej Urban, Filip Zavada, Miroslav Zavoral, Stanislav Rejchrt, Kristyna Hlavova, Jan Martinek, Bohumil Seifert |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Neurology medicine.drug_class business.industry Gastroenterology Proton-pump inhibitor Disease Health Surveys Risk Factors Physicians Surveys and Questionnaires Concomitant Internal medicine medicine Humans Corticosteroid Stomach Ulcer Neurosurgery Practice Patterns Physicians' Family history Complication business Glucocorticoids Czech Republic |
| Zdroj: | Scandinavian Journal of Gastroenterology. 45:1156-1161 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365521.2010.497935 |
| Popis: | Evidence does not support an association between systemic corticosteroid use and the development of peptic ulcer disease (PUD) and prophylactic anti-ulcer therapy is not routinely indicated. The aim was to find out the opinion of physicians in the Czech Republic on corticosteroid-induced ulcers.A questionnaire-based study targeting 360 physicians of different specialties (100 from Gastroenterology, 100 from General Practice, 80 from Pneumology/Immunology, and 80 from Neurology/Neurosurgery).Eighty-two percent of the physicians considered corticosteroids ulcerogenic, 7.5% of the responders considered them ulcerogenic only in patients with a family history of PUD, and 10.3% of the physicians considered corticosteroids non-ulcerogenic. Seventy-five percent of the responders would administer concomitant antisecretory treatment. Sixty-seven percent of the physicians thought that PUD was a frequent complication of corticosteroid therapy. If the ulcerogenic potential of ibuprofen, diclofenac, and prednisone was a subject of the physicians' judgment, a majority (40.5%) considered prednisone to be the most ulcerogenic substance. Thirty percent of gastroenterologists (vs. 1.9% of others; p0.001) did not consider corticosteroids to be ulcerogenic; 27.4% (vs. 4.3%; p0.01) would not administer an antisecretory prophylaxis routinely.Although there is no evidence showing an association between PUD and the use of corticosteroids, a majority of physicians consider corticosteroids gastrotoxic. This applies, to a lesser extent, to gastroenterologists. Action should be taken to explode the myth about the gastrotoxicity of corticosteroids and to minimize useless expenses on concomitant prophylaxis. |
| Databáze: | OpenAIRE |
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