Mycobacterium bovis genomics reveals transmission of infection between cattle and deer in Ireland
| Autor: | Susan Warde, Sophie Cassidy, Joseph Crispell, Kevin Kenny, Gianluigi Rossi, Teresa MacWhite, Stephen V. Gordon, Rowland R. Kao, John Moriarty, Henrietta Cameron, Guy McGrath, Samantha Lycett, Piran C. L. White |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Badger
040301 veterinary sciences Range (biology) Short Communication animal diseases Population Wildlife Zoology Biology Population density law.invention Bovine tuberculosis 0403 veterinary science 03 medical and health sciences Microbial evolution and epidemiology: Communicable disease genomics law biology.animal bovine tuberculosis education 030304 developmental biology badger 0303 health sciences education.field_of_study Mycobacterium bovis Host (biology) Deer 04 agricultural and veterinary sciences General Medicine biology.organism_classification phylogenetics Phylogenetics Transmission (mechanics) Wicklow deer |
| Zdroj: | Crispell, J, Cassidy, S, Kenny, K, McGrath, G, Warde, S, Cameron, H, Rossi, G, MacWhite, T, White, P C L, Lycett, S, Kao, R R, Moriarty, J & Gordon, S V 2020, ' Mycobacterium bovis genomics reveals transmission of infection between cattle and deer in Ireland ', Microbial Genomics . https://doi.org/10.1099/mgen.0.000388 Microbial Genomics |
| ISSN: | 2057-5858 |
| DOI: | 10.1099/mgen.0.000388 |
| Popis: | Control of bovine tuberculosis (bTB), caused byMycobacterium bovis, in the Republic of Ireland costs €84 million each year. Badgers are recognized as being a wildlife source forM. bovisinfection of cattle. Deer are thought to act as spillover hosts for infection; however, population density is recognized as an important driver in shifting their epidemiological role, and deer populations across the country have been increasing in density and range. County Wicklow represents one specific area in the Republic of Ireland with a high density of deer that has had consistently high bTB prevalence for over a decade, despite control operations in both cattle and badgers. Our research used whole-genome sequencing ofM. bovissourced from infected cattle, deer and badgers in County Wicklow to evaluate whether the epidemiological role of deer could have shifted from spillover host to source. Our analyses reveal that cattle and deer share highly similarM. bovisstrains, suggesting that transmission between these species is occurring in the area. In addition, the high level of diversity observed in the sampled deer population suggests deer may be acting as a source of infection for local cattle populations. These findings have important implications for the control and ultimate eradication of bTB in Ireland. |
| Databáze: | OpenAIRE |
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