Effects of sofalcone on necrotizing agents-induced gastric lesions and on endogenous prostaglandins in rats stomachs
| Autor: | Haruko Hirose, Ryuichi Saziki, Yoshihiko Isobe, Hironaka Aihara, Iwao Arai |
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| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Indomethacin Prostaglandin Endogeny Gastroenterology Dinoprostone chemistry.chemical_compound Necrosis Chalcone Chalcones Internal medicine medicine Animals Stomach Ulcer Prostaglandin E2 Antrum Pharmacology Propiophenones business.industry Stomach Prostaglandins E Biological activity Rats Inbred Strains Anti-Ulcer Agents Cytoprotection Rats medicine.anatomical_structure chemistry Gastric Mucosa Sofalcone Prostaglandins business medicine.drug |
| Zdroj: | Journal of pharmacobio-dynamics. 7(11) |
| ISSN: | 0386-846X |
| Popis: | Attempts were made to investigate the effect of 2'-carboxymethoxy 4, 4'-bis (3-methyl-2-butenyloxy) chalcone (sofalcone) on necrotizing agents-induced gastric lesions and on prostaglandin E2 (PGE2)-like activity of the gastric tissue in rats. 1. Sofalcone, 100 mg/kg i.p. and 300 mg/kg p.o., markedly suppressed 0.6 N HCl-or 100% Et0H-induced gastric lesions. Sofalcone, 100 mg/kg i.p., also significantly suppressed 0.2N NaOH-induced gastric lesions. 2. Sofalcone suppressed 0.6 N HCl-induced gastric lesions with both oral and intraperitoneal routes, and the effect was particularly marked at 60 min. A dose of 100 mg/kg i.p. showed suppression lasting for up to 300 min. 3. 0.6N HCl-induced gastric lesions were significantly aggravated by indomechacin treatment (10 mg/kg s.c.). Oral sofalcone (300 mg/kg) significantly suppressed the aggravation of gastric lesions by indomethacin given before and after sofalcone, but the i.p. (100 mg/kg) did not show significant suppression in the case of pretreatment with indomethacin. 4. PGs-like activity in the gastric tissue was increased in both of the fundus and the antrum by the administration of sofalcone without any dose-dependency. The increase was continuous and lasted for 6 h in the fundus of the stomach. |
| Databáze: | OpenAIRE |
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