BUSCANDO UNA CURVA GENERAL DE RESPUESTA A LA QUIMIOTERAPIA BASADA EN LA EVALUACIÓN RADIOLÓGICA CON CRITERIO RECIST

Autor:	Pamela Salman B., Mauricio Mahave C, Manuel Yañez G., Monzerrat Fernández G, Adolfo Barros R, Mauricio Canals L
Jazyk:	Spanish; Castilian
Rok vydání:	2009
Předmět:	Analysis of covariance medicine.medical_specialty RECIS business.industry Size reduction Objective method Curva de respuesta Regression Surgery Overall response rate medicine Radiology Nuclear Medicine and imaging Analysis of variance Nuclear medicine business Nonlinear regression
Zdroj:	Revista chilena de radiología v.15 n.2 2009 SciELO Chile CONICYT Chile instacron:CONICYT
Popis:	Radiological evaluation of response to chemotherapy can be carried out by applying the RECIST (Response Evaluation Criteria in Solid Tu- mors) criteria, currently considered the most objective method for monitoring lesions. Aimed at finding a general response curve, 21 patients with lung and kidney tumors, as well as colorectal carcinoma were studied between 2006 and 2008. Statistical proceedings included variance (ANOVA), co-variance (ANCOVA) and logarithmic regression analysis. Target-lesion size reduction, duration of response and overall response of different types of tumors did not differ significantly. A general response curve was obtained: log (RR i )= 1,897-0,028 t, where RR i is the relative RECIST count, and t is time (expressed in months). As an expected outcome -because of variety of drugs, type of tu- mors and variability rates in individual response- the determination coefficient in regression was 10.9%. However, it constitutes a first approach to solid tumors response and proves the accuracy and usefulness of RECIST methodology.
Databáze:	OpenAIRE
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