Translocation (15;17) and trisomy 21 in the microgranular variant of acute promyelocytic leukemia
| Autor: | Derrick W. Spell, Dennie V. Jones, William S. Velasquez, Gopalrao V.N. Velagaleti |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Acute promyelocytic leukemia Cancer Research medicine.medical_specialty Aneuploidy Chromosomal translocation Biology Translocation Genetic Myelogenous Leukemia Promyelocytic Acute Bone Marrow immune system diseases Genetics medicine Humans neoplasms Molecular Biology Chromosome Aberrations Chromosomes Human Pair 15 Cytogenetics Prognosis medicine.disease Cytogenetic Aberrations Leukemia Karyotyping Immunology Cancer research Down Syndrome Trisomy Chromosomes Human Pair 17 |
| Zdroj: | Cancer Genetics and Cytogenetics. 132:74-76 |
| ISSN: | 0165-4608 |
| Popis: | Cytogenetic abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as inv(16), t(8;21), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation t(15;17) characterizes acute promyelocytic leukemia (APL) (French-American-British [FAB] class M3) in almost all patients. Secondary chromosomal abnormalities are also present in approximately one-third of patients with newly diagnosed APL. We present a 26-year-old Hispanic man diagnosed with the microgranular variant of APL (FAB class M3v) whose initial cytogenetics included t(15;17) and trisomy 21. The prognostic implications of trisomy 21 and other secondary cytogenetic aberrations in APL are reviewed. To our knowledge, this is the first reported case of trisomy 21 with t(15;17) in the microgranular variant of APL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect