The Effect of Dietary Protein Imbalance during Pregnancy on the Growth, Metabolism and Circulatory Metabolome of Neonatal and Weaned Juvenile Porcine Offspring
| Autor: | Cornelia C. Metges, Iris S. Lang, Solvig Görs, Q. Sciascia, Jerzy Adamski, Gürbüz Daş, Cornelia Prehn, Winfried Otten |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Body Weight Carbohydrate And Urea Metabolism Maternal Protein Restriction Metabolomics Offspring Porcine Model medicine.medical_specialty Swine medicine.medical_treatment Biology Glucagon Article carbohydrate and urea metabolism body weight Pregnancy Placenta Internal medicine Carnitine Protein Deficiency medicine Dietary Carbohydrates Animals Urea TX341-641 maternal protein restriction Acetylcarnitine porcine model Triglycerides Nutrition and Dietetics offspring Nutrition. Foods and food supply Insulin Maternal Nutritional Physiological Phenomena Glucose Tolerance Test medicine.disease metabolomics Endocrinology medicine.anatomical_structure Glucose Animals Newborn Prenatal Exposure Delayed Effects Metabolome Gestation Female Dietary Proteins Food Science Hormone medicine.drug |
| Zdroj: | Nutrients Volume 13 Issue 9 Nutrients 13:3286 (2021) Nutrients, Vol 13, Iss 3286, p 3286 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13093286 |
| Popis: | Protein imbalance during pregnancy affects women in underdeveloped and developing countries and is associated with compromised offspring growth and an increased risk of metabolic diseases in later life. We studied in a porcine model the glucose and urea metabolism, and circulatory hormone and metabolite profile of offspring exposed during gestation, to maternal isoenergetic low–high (LP-HC), high–low (HP-LC) or adequate (AP) protein–carbohydrate ratio diets. At birth, LP-HC were lighter and the plasma acetylcarnitine to free carnitine ratios at 1 day of life was lower compared to AP offspring. Plasma urea concentrations were lower in 1 day old LP-HC offspring than HP-LC. In the juvenile period, increased insulin concentrations were observed in LP-HC and HP-LC offspring compared to AP, as was body weight from HP-LC compared to LP-HC. Plasma triglyceride concentrations were lower in 80 than 1 day old HP-LC offspring, and glucagon concentrations lower in 80 than 1 day old AP and HP-LC offspring. Plasma urea and the ratio of glucagon to insulin were lower in all 80 than 1 day old offspring. Aminoacyl-tRNA, arginine and phenylalanine, tyrosine and tryptophan metabolism, histidine and beta-alanine metabolism differed between 1 and 80 day old AP and HP-LC offspring. Maternal protein imbalance throughout pregnancy did not result in significant consequences in offspring metabolism compared to AP, indicating enormous plasticity by the placenta and developing offspring. |
| Databáze: | OpenAIRE |
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