Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus
Autor: | Lindsay Basto, Roi Anteby, Laurencia Perea, Aaron Lucander, Celeste C. Thomas, Martin Tibudan, Gabriela S. Generette, Damian Grybowski, Karolina Golab, Piotr J. Bachul, John J. Fung, Ling Jia Wang, Jordan Pyda, Piotr Witkowski |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
endocrine system endocrine system diseases autoantibodies 030209 endocrinology & metabolism 030230 surgery Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Antigen GADA Internal medicine medicine pancreas Seroconversion Insulinoma Type 1 diabetes geography geography.geographical_feature_category biology business.industry Autoantibody General Medicine allogenic islet cell transplantation medicine.disease Islet Transplantation biology.protein Medicine Antibody business type 1 diabetes mellitus |
Zdroj: | Journal of Clinical Medicine Volume 10 Issue 12 Journal of Clinical Medicine, Vol 10, Iss 2708, p 2708 (2021) |
ISSN: | 2077-0383 |
DOI: | 10.3390/jcm10122708 |
Popis: | (1) Background: The correlation between titers of islet autoantibodies (IAbs) and the loss of transplanted islets remains controversial. We sought to evaluate the prognostic utility of monitoring IAbs in diabetic patients after islet transplantation (ITx) (2) Methods: Twelve patients with Type 1 diabetes mellitus and severe hypoglycemia underwent ITx. Serum concentration of glutamic acid decarboxylase (GAD), insulinoma antigen 2 (IA-2), and zinc transport 8 (ZnT8) autoantibodies was assessed before ITx and 0, 7, and 75 days and every 3 months post-operatively (3) Results: IA-2A (IA-2 antibody) and ZnT8A (ZnT8 antibody) levels were not detectable before or after ITx in all patients (median follow-up of 53 months (range 24–61)). Prior to ITx, GAD antibody (GADA) was undetectable in 67% (8/12) of patients. Of those, 75% (6/8) converted to GADA+ after ITx. In 67% (4/6) of patients with GADA+ seroconversion, GADA level peaked within 3 months after ITx and subsequently declined. All patients with GADA+ seroconversion maintained long-term partial or complete islet function (insulin independence) after 1 or 2 ITx. There was no correlation between the presence of IAb-associated HLA haplotypes and the presence of IAbs before or after ITx (4) Conclusions: There is no association between serum GADA trends and ITx outcomes. IA-2A and ZnT8A were not detectable in any of our patients before or after ITx. |
Databáze: | OpenAIRE |
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