Low-Frequency Transcranial Magnetic Stimulation over Left Dorsal Premotor Cortex Improves the Dynamic Control of Visuospatially Cued Actions
| Autor: | Sven Bestmann, Hartwig R. Siebner, John C. Rothwell, Richard S.J. Frackowiak, Gesa Hartwigsen, Lars O. D. Christensen, M. M. Weiss, Nick S. Ward |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_treatment Posterior parietal cortex Neuropsychological Tests behavioral disciplines and activities Brain mapping Functional Laterality Article Premotor cortex Young Adult Supramarginal gyrus Image Processing Computer-Assisted Reaction Time medicine Humans Analysis of Variance Brain Mapping medicine.diagnostic_test General Neuroscience Middle Aged Magnetic Resonance Imaging Transcranial Magnetic Stimulation Frontal Lobe Oxygen Transcranial magnetic stimulation medicine.anatomical_structure nervous system Frontal lobe Space Perception Cues Stimulus–response compatibility Functional magnetic resonance imaging Psychology Neuroscience Photic Stimulation psychological phenomena and processes |
| Zdroj: | Journal of Neuroscience. 30:9216-9223 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.4499-09.2010 |
| Popis: | Left rostral dorsal premotor cortex (rPMd) and supramarginal gyrus (SMG) have been implicated in the dynamic control of actions. In 12 right-handed healthy individuals we applied 30 minutes of low-frequency (1Hz) repetitive transcranial magnetic stimulation (rTMS) over left rPMd to investigate the involvement of left rPMd and SMG in the rapid adjustment of actions guided by visuospatial cues. After rTMS, subjects underwent functional magnetic resonance imaging while making spatially congruent button presses with right or left index finger in response to a left- or right-sided target. Subjects were asked to covertly prepare motor responses as indicated by a directional cue presented one second before the target. On 20% of trials the cue was invalid requiring subjects to re-adjust their motor plan according to the target location. Compared to sham rTMS, real rTMS increased the number of correct responses in invalidly cued trials. After real rTMS, task-related activity of the stimulated left rPMd showed increased task-related coupling with activity in ipsilateral SMG and adjacent anterior intraparietal area (AIP). Individuals who showed a stronger increase in left-hemispheric premotor-parietal connectivity also made fewer errors on invalidly cued trials after rTMS. The results suggest that rTMS over left rPMd improved the ability to dynamically adjust visuospatial response mapping by strengthening left-hemispheric connectivity between rPMd and the SMG-AIP region. These results support the notion that left rPMd and SMG-AIP contribute towards dynamic control of actions, and demonstrate that low-frequency rTMS can enhance functional coupling between task-relevant brain regions and improve some aspects of motor performance. |
| Databáze: | OpenAIRE |
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