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Ciechański Erwin, Ciechańska Magda, Ciechański Krystian, Szponar Jarosław. Long QT syndrome- causes and risk factors. Journal of Education, Health and Sport. 2018;8(10):111-116. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1461597 http://ojs.ukw.edu.pl/index.php/johs/article/view/6171 https://pbn.nauka.gov.pl/sedno-webapp/works/882478 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 22.09.2018. Revised: 28.09.2018. Accepted: 13.10.2018. Long QT syndrome - causes and risk factors Erwin Ciechański1, Magda Ciechańska1, Krystian Ciechański2, Jarosław Szponar1 1Department of Toxicology, Medical University of Lublin 2Student’s Research Group at the Department of Toxicology, Medical University of Lublin Abstract Sudden cardiac deathis a major public health challenge, which can be caused by genetic or acquired structural or electrophysiological abnormalities. These abnormalities include channelopathies such as long QT,short QT and Brugada syndromes. Long QT syndrome is a cardiac repolarization disorder and is associated with an increased risk of torsades de pointes (TdP). Main causes of acquired syndrome are specific medications and/or electrolytes imbalance. On the other hand common congenital causes are Jervell and Lange-Nielsen or Romano- Ward syndromes. Patients with risk factors, treated with specified QT prolongating drugs always require slow dose titration and electrocardiography monitoring. Aim of this study is to comprehensively and critically review the pathomechanisms of QT prolongation, risk factors and prevention methods. Key words: Long QT syndrome, sudden cardiac death, QT prolongating drugs, channelopathies. |
