Overlaying Molecular and Temporal Aspects of Malaria Parasite Invasion
Autor: | Paul R. Gilson, Brendan S. Crabb, Greta E. Weiss |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Erythrocytes Plasmodium falciparum Protozoan Proteins Parasitemia Ligands 03 medical and health sciences 0302 clinical medicine Antigen Live cell imaging Malaria Vaccines parasitic diseases medicine Humans Parasite hosting Malaria Falciparum Pathogen Life Cycle Stages biology biology.organism_classification medicine.disease Virology 030104 developmental biology Infectious Diseases biology.protein Parasitology Antibody Malaria 030215 immunology |
Zdroj: | Trends in Parasitology. 32:284-295 |
ISSN: | 1471-4922 |
Popis: | A highly-effective, long-lasting vaccine, targeting multiple stages of the Plasmodium falciparum life cycle, is likely to be important for the elimination of this pathogen. Key antigens of this vaccine would produce host antibodies that block the ligands required for merozoite invasion of erythrocytes, thereby curtailing the expansion of parasitemia and symptomatic disease. Recent live cell imaging of invading Plasmodium falciparum merozoites with various receptor–ligand interactions inhibited has provided new information about the function, sequence, and timing of these events, providing a rationale for a vaccine containing multiple antigens that inhibit the sequential steps of invasion. |
Databáze: | OpenAIRE |
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